Torsemide

Torsemide is a loop diuretic drug used for treatment of high blood pressure (hypertension). It acts by inhibiting the Na+/ K+/ 2Cl– carrier system (via interference of the chloride binding site) in the lumen of the thick ascending portion of the loop of Henle, resulting in the decrease in reabsorption of sodium and chloride.

Molecular structure:

• Molecular formula: C₁₆H₂₀CIN₄O₃S
• Molecular weight: 348.82
• CAS Number: 56211-40-6
• Application: used for oedema associated with heart failure, including pulmonary oedema and with renal and hepatic disorders. It is also used in the treatment of hypertension.
• Specification: As per IP/USP/IHS

IUPAC Name/ACD Name:
N-(Isopropylcarbamoyl)-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide

Chemical Name:
3-Pyridinesulfonamide,
N-[[(1-methyl ethyl) amino]carbonyl]-4-[(3-methylphenyl) amino]-1-isopropyl-3 [(4-m-toludino-3-pyridyl)sulfonyl]urea